Publications (2003-2021)





Bento-Oliveira, A.; Santos, F.C.; Marquês, J.T.; Paulo, P.M.R.; Korte, T.; Herrmann, A.; Marinho, H.S.; de Almeida, R.F.M. (2020) Yeast Sphingolipid-Enriched Domains and Membrane Compartments in the Absence of Mannosyldiinositolphosphorylceramide. Biomolecules10, 871.

Khmelinskaia A, Marquês JMT, Bastos AEP, Antunes CAC, Bento-Oliveira A, Scolari S, Lobo GMDS, Malhó R, Herrmann A, Marinho HS, de Almeida RFM. (2020)Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences. Front Cell Dev Biol. 8:337. doi: 10.3389/fcell.2020.00337.

V. Pinto, R.; Antunes, F.; Pires, J.; Silva-Herdade, A.; Pinto, M.L. (2020) A Comparison of Different Approaches to Quantify Nitric Oxide Release from NO-Releasing Materials in Relevant Biological Media. Molecules , 25, 2580.

R. V. Pinto, S. Wang, S. R. Tavares, J. Pires, F. Antunes, A. Vimont, G. Clet, M. Daturi, G. Maurin, C. Serre, M. L. Pinto, Angew. Chem. Int. Ed. 202059, 5135.

Soares H, Sunter JD, Wloga D, Joachimiak E, Miceli C. Trypanosoma, Paramecium and Tetrahymena: From genomics to flagellar and ciliary structures and cytoskeleton dynamics. Eur J Protistol. 2020 Oct;76:125722. doi: 10.1016/j.ejop.2020.125722. Epub 2020 Jun 10. PMID: 32679518.

Delgado ILS, Carmona B, Nolasco S, Santos D, Leitão A, Soares H. MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis. Biology (Basel). 2020 Nov 24;9(12):413. doi: 10.3390/biology9120413. PMID: 33255245; PMCID: PMC7761452.



Lyublinskaya, O., Antunes, F. (2019) Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H2O2 biosensor HyPer. Redox Biology, 24, 101200. doi: 10.1016/j.redox.2019.101200.

Santos, T., Marinho, H.S., Cyrne, L. (2019) Inositol transporters regulation by hydrogen peroxide in S. cerevisiae. Arch. Microbiol. 201, 123-134. DOI: 10.1007/s00203-018-1584-1.

Cardoso, B.A., Ramos, T.L., Belo, H., Vilas-Boas, F., Real, C., Almeida, A.M. (2019) Vorinostat synergizes with antioxidant therapy to target myeloproliferative neoplasms. Exp Hematol. 72: 60-71. e11. pii: S0301-472X(19)30069-4. doi: 10.1016/j.exphem.2019.02.002.

Soares H, Carmona B, Nolasco S, Viseu Melo L, Gonçalves J. Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures. Cells. 2019 Feb 14;8(2):160. doi: 10.3390/cells8020160.

Soares H, Carmona B, Nolasco S, Viseu Melo L. Polarity in Ciliate Models: From Cilia to Cell Architecture. Front Cell Dev Biol. 2019 Oct 18;7:240. doi: 10.3389/fcell.2019.00240.



Marinho, H.S., Marcelino, P., Soares, H., Corvo, M.L. (2018) Gene silencing using siRNA for preventing liver ischaemia-reperfusion injury. Curr. Pharm. Des. 24, 1-9.doi: 10.2174/1381612824666180807124356.

Domènech, A., Ayté, J., Antunes, F., Hidalgo, E. (2018) Using in vivo oxidation status of one-and two-component redox relays to determine H2O2 levels linked to signaling and toxicity. BMC Biology, 16, 61. doi:10.1186/s12915-018-0523-6.

Marquês, J. T., Marinho, H.S., de Almeida, R.F.M. (2018) Sphingolipid hydroxylation in mammals, yeast and plants – an integrated view. Prog. Lipid Res. 71, 18-42. doi: 10.1016/j.plipres.2018.05.001

Bento, R.N., Rendas, M.A., Bernardes, C.E.S., Santos, M. S. C. S., Antunes, F., Minas da Piedade, M.E (2018) Kinetics of the base catalysed hydrolysis of methyl paraben revisited: Implications for determination of the effective volume of flow-microcalorimeters used to study cell cultures. Thermochimica Acta, 659, 82-88. doi: 10.1016/j.tca.2017.11.008



Seixas, C., Gonçalves, J. Melo, L.V., Soares, H. (2017) Tetrahymena cilia cap is built in a multi-step process: a study by atomic force microscopy. Protist, 168, 697-717. doi:10.1016/j.protis.2017.10.001.

Jerónimo, A. , Rodrigues, G., Vilas-Boas, F., Martins, G.G., Bagulho, A., Real, C. (2017) Hydrogen peroxide regulates angiogenesis-related factors in tumor cells. Biochemistry and Cell Biology. 95:679-685. doi:10.1139/bcb-2017-0083.

Marcelino, P., Marinho, H.S., Campos, M.C., Neves, A.R., Real, C., Fontes, F.S., Carvalho, A., Feio, G., Martins, M.B.F., Corvo, M.L. (2017) Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. European J. Pharmacol. Sci.  109, 464-471. doi:10.1016/j.ejps.2017.09.008.

Camelo, C., Vilas-Boas, F., Cepeda, A. P., Real, C., Barros-Martins, J., Pinto, F., Soares, H., Marinho, H.S., Cyrne, L. (2017) Opi1p translocation to the nucleus is regulated by hydrogen peroxide in Saccharomyces cerevisiae.  Yeast. 34, 383-395. doi:10.1002/yea.3240

Egea, J. [...], Antunes, F. et al (2017) European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) Redox Biol., 13, 94-162 doi:10.1016/j.redox.2017.05.007

Antunes, F., Brito, P.M. (2017) Quantitative biology of hydrogen peroxide signaling. Redox Biol. 13, 1-7. doi: 10.1016/j.redox.2017.04.039

Pinto, R.V., Antunes, F., Pires,J., Graça, V., Brandão, P., Pinto, M.L. (2017) Vitamin B3 metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide. Acta biomaterialia 51, 66-74. doi: 10.1016/j.actbio.2017.01.039

Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W. (2017) Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy (Alexandru Mihai Grumezescu and Anton Ficai, ed.) Chapter 27, pp.749-774. Elsevier. doi: 10.1016/B978-0-323-46144-3.00027-1

Gomes, A.Q., Real, C., Antunes, F., Marinho, H.S., Nolasco, S. and Soares, H. (2017). Non-coding RNAs as critical players in regulatory accuracy, redox signaling and immune cell functions. In Current Developments in Biotechnology and Bioengineering, Book 9: Biotechnology in Human and Animal Health, (Vanete Thomaz-Soccol, Rodrigo R. Resende, Ashok Pandey, eds.), Chapter 10, pp. 215-284. Elsevier.

Dömötör, O,, de Almeida, R.F., Côrte-Real, L., Matos, C.P., Marques, F., Matos, A., Real, C., Kiss, T., Enyedy, É.A., Garcia, M.H., Tomaz, A.I. (2017) Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes. J. Inorg. Biochem. 168, 27-37. doi: 10.1016/j.jinorgbio.2016.12.008..

Santos, F.C., Fernandes, A.S., Antunes, C.A.C., Moreira, F. P., Videira, A., Marinho, H.S., de Almeida, R.F.M. (2017) Reorganization of plasma membrane lipid domains during conidial germination. Biochim. Biophys. Acta - Molecular and Cell Biology of Lipids. 1862, 156-166 doi: 10.1016/j.bbalip.2016.10.011



Netto, L.E.S., Antunes, F. (2016) The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction. Mol. Cells. 39, 65–71. doi:  10.14348/molcells.2016.2349.

Vilas-Boas, F., Bagulho, A., Jerónimo, A., Tenente, R., Real, C. (2016) Data on intracellular localization of RPSA upon alteration of its redox state. Data in Brief, 6, 311-315.
Vilas-Boas, F., Bagulho, A, Tenente, R, Teixeira, V.H., Martins, G., da Costa, G., Jerónimo, A., Cordeiro, C., Machuqueiro, M., Real, C. (2016) Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA. Free Radic. Biol. Med. 90:145-57. doi: j.freeradbiomed.2015.11.019.

Rodrigues, C., Mósca, A.F., Martins, A.P., Nobre, T., Prista, C., Antunes, F., Gasparovic, A.C., Soveral, G. (2016) Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress. International Journal of Molecular Science, 17, 2090. http://10.3390/ijms17122090

Guerreiro, P.S., Estácio, S.G., Antunes, F., Fernandes, A.S., Pinheiro, P.F., Costa, J.G., Castro, M., Miranda, J.P., Guedes, R.C., Oliveira, N.G. (2016) Structure-based virtual screening: towards the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chemical Biology & Drug Design, 88, 915–925.

Bento, R.N., Rendas, M.A., Semedo, V.A.R., Bernardes, C.E.S., Santos, M.S.C.S., Diogo, H.P., . Antunes, F., Minas da Piedade, M.E. (2016) The standard molar enthalpy of the base catalysed hydrolysis of methyl paraben revisited. Journal of Chemical Thermodynamics, 103, 176-180. doi: 10.1016/j.jct.2016.07.042

Fernandes, A.C., Pinto, M.L., Antunes, F., Pires, J. (2016) Synthetic cobalt clays for the storage and slow release of therapeutic nitric oxide. RSC Advances, 6, 41195-41203. doi: 10.1039/C6RA05794B

Pinto, M.L., Fernandes, A.C., Antunes, F., Pires, J., Rocha, J. (2016) Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues. Microporous and Mesoporous Materials, 229, 83-89. doi:10.1016/j.micromeso.2016.04.021.

Cardoso, R., Soares, H., Hemphill, A., Leitão, A. (2016) Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology. 4:1-14. doi:10.1017/S0031182016000524

Corvo, M.L., Marinho, H.S., Martins, M.B.F. (2016) Nanomedicines as a strategy for the therapeutic use of superoxide dismutases, in Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. (Nancy H. Phillips, ed.), Chapter 4, pp.135-170. NY: Nova Publishers.

Carmona, B., Tavares, A., Nolasco, S., Leitão, A, Soares, H. (2016) MOB1A in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-7, Springer: New York. doi:10.1007/978-1-4614-6438-9_101509-1.

Camelo, C., Peneda, C., Carmona, B., Soares, H. (2016) TBBC in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-8, Springer: New York. doi:10.1007/978-1-4614-6438-9_101508-1.

Nolasco, S., Gonçalves, J., Soares, H. (2016) CCTA in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-10, Springer: New York. doi:10.1007/978-1-4614-6438-9_550-1

Gonçalves, J., Soares, H. (2016) TBBCD1 in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-6, Springer: New York. doi:10.1007/978-1-4614-6438-9_551-1



Bagulho, A., Vilas-Boas, F., Pena, A., Peneda, C., Santos, F.C., Jerónimo, A., de Almeida, R.F.M.,  Real, C., (2015) The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells. Redox Biol., 6, 454–460. doi:10.1016/j.redox.2015.09.006

Marquês, J.T., Cordeiro, A.M., Viana, A.S., Herrmann, A., Marinho, H.S., de Almeida, R.F. (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir, 31, 9410−9421 doi: 10.1021/acs.langmuir.5b02550

Fernandes, A.C., Pinto, M.L., Antunes, F., Pires, J. (2015) l-Histidine-based organoclays for the storage and release of therapeutic nitric oxide. Journal of Materials Chemistry B, 3, 3556-3563. DOI: 10.1039/C4TB01913J

Corvo, M.L., Marinho, H.S., Marcelino, P. Lopes, R., Vale, C.A., Marques, C., Martins L.C.D., Laverman, P., Storm, G., Martins, M.B.F. (2015) Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm. Res. 32 :91-102. doi: 10.1007/s11095-014-1447-7.

Marinho, H.S., Antunes F. (2015) Metabolism of superoxide radical and hydrogen peroxide in mitochondria in Mitochondria in Liver Disease (Derick Han and Neil Kaplowitz, ed.) Chapter 1, pp. 1- 28. Boca Raton: CRC Press.



Benfeitas, R., Selvaggio, G., Antunes, F., Coelho, P.M.B.M., Salvador, A. (2014) Hydrogen peroxide metabolism and sensing in human erythrocytes: a validated kinetic model and reappraisal of the role of peroxiredoxin II, Free Radic. Biol. Med. 74, 35-49. doi. 10.1016/j.freeradbiomed.2014.06.007.

Cardoso, R., Nolasco, S., Gonçalves, J., Cortes, H.C., Leitão, A., Soares, H.  (2014)  Besnoitia besnoiti and Toxoplasma gondii: two apicomplexan strategies to manipulate the host cell centrosome and Golgi apparatus  Parasitology  3, 1-19. DOI: 10.1017/S0031182014000493.

Brito, P.M., Antunes, F. (2014) Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins. Front. Chem., 2014, 2:82. doi: 10.3389/fchem.2014.00082

Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006.ISI highly cited paper (Top 1% in Biology and Biochemistry)

Soares, H., Marinho H.S., Real, C., Antunes, F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr. 9, 371 doi: 10.1007/s12263-013-0371-5. Chosen as a key scientific article by Global Medical Discovery.

Martins, M.B.F., Corvo, M.L., Marcelino, P., Marinho, H.S., Feio, G., Carvalho, A. (2014) New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI.  Nanomed.-Nanotechnol. Biol. Med. 10, 207-214. doi:10.1016/j.nano.2013.06.008.

Pinto, M.L.; Fernandes, A.C.; Rocha, J.; Ferreira, A.; Antunes, F.; Pires, J. (2014) Microporous titanosilicates Cu2+– and Co2+–ETS-4 for storage and slow release of therapeutic nitric oxide. J. Mater. Chem. B, 2, 224-230. doi: 10.1039/C3TB20929F



Gomes, A.Q., Nolasco, S., Soares, H. (2013) Non-Coding RNAs: Multi-Tasking Molecules in the Cell. Int. J. Mol. Sci. 14,16010-39. doi: 10.3390/ijms140816010.

da Silva,J.P.,Antunes, F., Pinto,M.L., Fernandes, A. (2013) Clay based materials for storage and therapeutic release of nitric oxide. J. Mater. Chem. B., 1, 3287-3294.DOI: 10.1039/C3TB20535E

Oliveira-Marques, V., Silva, T., Cunha, F., Covas, G., Marinho, H.S., Antunes, F., Cyrne, L. (2013) A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-α. Redox Biol., 1, 347–352. doi:10.1016/j.redox.2013.05.004.

Marinho, H.S., Cyrne, L., Cadenas, E., Antunes, F. (2013) H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol. 526, 159-176. doi:10.1016/B978-0-12-405883-5.00010-7.

Marinho, H.S., Cyrne, L., Cadenas E., Antunes, F. (2013) The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol. 527, 3-19. doi:10.1016/B978-0-12-405882-8.00001-5.

Cyrne, L., Oliveira-Marques, V., Marinho, H.S., Antunes, F. (2013) H2O2 in the induction of NF-κB-dependent selective gene expression. Methods Enzymol. 528, 173-188. doi:10.1016/B978-0-12-405881-1.00010-0

Covas, G., Marinho, H.S., Cyrne, L., Antunes, F. (2013) Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation. Methods Enzymol. 528, 157-171. doi:10.1016/B978-0-12-405881-1.00009-4.

Carranza, G., Castaño, R., Fanarraga, M.L., Villegas, J.C., Gonçalves, J., Soares, H., Avila, J., Marenchino, M., Campos-Olivas, R., Montoya, G., Zabala, J.C. (2013) Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics. Cell Mol Life Sci., 70, 357-371. DOI: 10.1007/s00018-012-1114-2 [pdf]

Rodrigues, J.R., Ferrer,R. Gamboa, N., Antunes, F. (2013) Potential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR) J. Enzyme Inhib. Med. Chem. 28: 1300-1306. doi:10.3109/14756366.2012.

Fernandes, A.C.; Antunes, F.; Pires, J. (2013) Sepiolite based materials for storage and slow release of nitric oxide. New J. Chem.,37, 4052-4060. doi: 10.1039/C3NJ00452J



Nolasco, S, Bellido, J, Gonçalves, J, Tavares, A., Zabala, J.C., Soares, H. (2012) The Expression of Tubulin Cofactor A (TBCA) Is Regulated by a Noncoding Antisense Tbca RNA during Testis Maturation. PLoS One 7(8):e42536.[pdf]

Pedroso, N., Gomes-Alves, P., Marinho, H.S., Brito, V.B., Boada, C., Antunes, F., Herrero, E., Penque, D., Cyrne, L. (2012) The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Free Radical Res. 46, 1267-1279. doi:10.3109/10715762.2012.704997

Bastos, A.E.P., Marinho, H.S., Cordeiro, A.M., Soure, A.M., de Almeida, R.F.M. (2012) Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. Chem. Phys.  Lipids. 165, 577-588. doi:10.1016/j.chemphyslip.2012.06.002

Rodrigues,J.R., Charris, J., Camacho,J., Barazarte,A., Gamboa,N., Antunes, F. (2012) Cytotoxic effects of N´-formyl-2-(5-nitrothiophen-2-yl)benzothiazole-6-carbohydrazide in human breast tumor cells by induction of oxidative stress. Anticancer Research, 32, 2721-2726.

Tavares, A., Gonçalves, J., Florindo, C. Tavares,A.A., Soares, H. (2012) Mob1: defining cell polarity for proper cell division. J. Cell Sci., 125, 516-527. doi: 10.1242/jcs.096610. Chosen as key scientific article by Global Medical Discovery.

Basto, A.P., Piedade, J., Ramalho, R., Alves, S., Soares, H., Cornelis, P., Martins, C., Leitão, A. (2012) A new cloning system based on the OprI lipoprotein for the production of recombinant bacterial cell wall-derived immunogenic formulations. J. Biotechol. 157(1):50-63. doi:10.1016/j.jbiotec.2011.11.006

Baptista M, Silveira A, Antunes F. (2012) Theoretical analysis of the kinetic performance of laboratory- and full-scale composting systems. Waste Manag Res. 30, 700-707. DOI: 10.1177/0734242X11433528

Soares, H., Nolasco, S., Gonçalves, J. (2012) CCTa. Encyclopedia of Signaling Molecules (S. Choi, Editor), Springer, pp. 282-288,

Gonçalves, J., Soares, H. (2012) TBCCD1. Encyclopedia of Signaling Molecules (S. Choi, Editor) Springer, pp. 1831-1835



Matias, A., Marinho, H.S., Cyrne, L., Herrero, E., Antunes, F. (2011) Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 515, 107-111, doi:10.1016/[abstract][pdf].

Aresta-Branco, F., Cordeiro, A.M., Marinho, H.S., Cyrne, L., Antunes, F., de Almeida, R.F.M. (2011) Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered, ergosterol-free, sphingolipid-enriched lipid rafts. J. Biol. Chem.,286, 5043-5054, doi:10.1074/jbc.M110.154435.[abstract][pdf].

Real, C., Remédio, L., Caiado, F., Igreja, C., Borges, C., Trindade, A., Pinto-do-Ó, P., Yagita, H. Duarte, A., Dias, S. (2011) Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. PLoS One. 6:e18323. doi:10.1371/journal.pone.0018323.

Baptista, M. Antunes,F., Silveira, A. (2011) Diagnosis and optimization of the composting process in full-scale mechanical-biological treatment plants. Waste Manag. Res29, 565-573. doi: 10.1177/0734242X10388061.

Silva, A., Gírio, A., Cebola, I., Santos,C., Antunes, F., Barata, J.T. (2011) Intracellular Reactive Oxygen Species are Essential for PI3K-dependent IL-7-mediated Viability of T-cell Acute Lymphoblastic Leukemia Cells. Leukemia 25, 960-967. doi:10.1038/leu.2011.56.



Cyrne, L., Antunes, F., Sousa-Lopes, A., Diaz-Bérrio, J., Marinho, H.S. (2010) Glyceraldehyde-3-phosphate dehydrogenase is largely unresponsive to low regulatory levels of hydrogen peroxide in Saccharomyces cerevisiae. BMC Biochemistry, 11, 49. [abstract][pdf]

Gonçalves, J., Nolasco, S., Nascimento, R., Lopez Fanarraga, M., Zabala, J.C., Soares, H.(2010) TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. EMBO Rep., 11, 194-200. [abstract][pdf]

Gonçalves, J., Tavares,A., Carvalhal, S.,Soares, H. (2010) Revisiting the tubulin folding pathway: new roles in centrosomes and cilia. Biomol. Concepts 1, 423-434. [abstract][pdf]

Baptista, M; Antunes, F; Goncalves, MS; et al. (2010) Composting kinetics in full-scale mechanical-biological treatment plants. Waste Management, 30, 1908-1921.

Brito, P.H., Guilherme, E., Soares, H., Gordo, I. (2010) Mutation accumulation in Tetrahymena. BMC Evolutionary Biology, 10:354. doi:10.1186/1471-2148-10-354

Seixas,C. Cruto,T. Tavares,A. Gaertig,J. Soares, H. (2010) CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena PLoS One , 5:e10704.



Pedroso, N., Matias, A.C., Cyrne, L., Antunes, F., Borges, C., Malhó, R., de Almeida, R.F.M., Herrero, E. & Marinho, H.S. (2009) Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. Free Radic. Biol. Med. 46, 289-298.[abstract][pdf]

Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Role of hydrogen peroxide in NF-kB activation: from inducer to modulator. Antioxid. Redox Signal., 11, 2223-2243. [abstract][pdf]

Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Modulation of NF-kB-dependent gene expression by H2O2: a major role for a simple chemical process in a complex biological response. Antioxid. Redox Signal., 11, 2043-2053.[abstract][pdf]



Folmer, V., Pedroso, N., Matias, A.C., Lopes, S.C.D.N., Antunes, F., Cyrne, L. & Marinho, H.S. (2008) H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta - Biomembranes 1778, 1141-1147.[abstract][pdf]



Matias, A.C., Pedroso, N., Teodoro, N., Marinho, H.S., Antunes, F., Nogueira, J.M., Herrero, E., & Cyrne, L. (2007) Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. Free Radic. Biol. Med., 43, 1458-65.[abstract][pdf]

Oliveira-Marques, V., Cyrne, L., Marinho, H.S., Antunes, F. (2007) A quantitative study of NF-kB activation by H2O2: relevance in inflammation and synergy with TNF-alfa. J. Immunol. 178, 3893-3902. [abstract][pdf]

Antunes F., Boveris, A., Cadenas. E. (2007) On the biologic role of the reaction of NO with oxidized cytochrome c oxidase. Antioxid. Redox Signal., 9,1569-79.[abstract]

Antunes, F. Cadenas, E. (2007) The mechanism of cytochrome c oxidase inhibition by nitric oxide. Front. Biosci. , 12, 975-985.



Alves, R., Antunes, F., Salvador, A. (2006) Tools for kinetic modeling of biochemical networks. Nat. Biotechnol., 24, 667-762. [abstract]



Antunes,F. Nunes, C. Laranjinha,J. Cadenas, E. (2005) Redox Interactions of Nitric Oxide with Dopamine and its Derivatives. Toxicology, 208, 207-212. [abstract]



Antunes F., Boveris, A., Cadenas. E. (2004) On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc. Natl. Acad. Sci. USA, 101,16774-16779. [abstract][pdf]

Sousa-Lopes, A., Antunes, F., Cyrne, L., Marinho, H.S. (2004) Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress. FEBS Lett. 578, 152-156. [abstract] [pdf]

Branco, M.R., Marinho, H.S., Cyrne, L., Antunes, F. (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem., 279, 6501-6506 [abstract] [pdf]



Cyrne, L., Martins, L., Fernandes, L., Marinho, H.S. (2003) Regulation of antioxidant enzymes gene expression in the yeast Saccharomyces cerevisiae during stationary phase. Free Radic. Biol. Med., 34, 385-393. [abstract][pdf]

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D. Han, F. Antunes, R. Canali, D. Rettori, E. Cadenas.(2003) Voltage-Dependent Anion Channels Control the Release of Superoxide Anion from Mitochondria to Cytosol. J. Biol. Chem., 278, 5557-5563.

M. Zhao, F. Antunes, J. W. Eaton, U. T. Brunk. (2003) Lysosomal Enzymes Promote Mitochondrial Oxidant Production, Cytochrome c Release and Apoptosis. European J. Biochem., 270, 3778-3886.