Publications (2003-2017)

 

REVIEWS

 

  • Egea, J. [...], Antunes, F. et al (2017) European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) Redox Biol., 13, 94-162 doi:10.1016/j.redox.2017.05.007
  • Antunes, F., Brito, P.M. (2017) Quantitative biology of hydrogen peroxide signaling. Redox Biol. 13, 1-7.doi: 10.1016/j.redox.2017.04.039
  • Gomes, A.Q., Real, C., Antunes, F., Marinho, H.S., Nolasco, S. and Soares, H. (2017). Non-coding RNAs as critical players in regulatory accuracy, redox signaling and immune cell functions. In Current Developments in Biotechnology and Bioengineering, Book 9: Biotechnology in Human and Animal Health, (Vanete Thomaz-Soccol, Rodrigo R. Resende, Ashok Pandey, eds.), Chapter 10, pp. 215-284. Elsevier. doi: 10.1016/B978-0-444-63660-7.00010-3
  • Praça, F.S., Marinho, H.S., Martins, M.B.F., Gaspar, R.S., Corvo, M.L., Medina, W. (2017) Current aspects of breast cancer therapy and diagnosis based on a nanocarrier approach, in Nanostructures for Cancer Therapy(Alexandru Mihai Grumezescu and Anton Ficai, ed.) Chapter 27, pp.749-774. Elsevier. doi: 10.1016/B978-0-323-46144-3.00027-1
  • Netto, L.E.S., Antunes, F. (2016) The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction. Mol. Cells. 39, 65–71. doi:  10.14348/molcells.2016.2349.
  • Corvo, M.L., Marinho, H.S., Martins, M.B.F. (2016) Nanomedicines as a strategy for the therapeutic use of superoxide dismutases, in Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. (Nancy H. Phillips, ed.), Chapter 4, pp.135-170. NY: Nova Publishers.
  • Carmona, B., Tavares, A., Nolasco, S., Leitão, A, Soares, H. (2016) MOB1A in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-7, Springer: New York. doi:10.1007/978-1-4614-6438-9_101509-1.
  • Camelo, C., Peneda, C., Carmona, B., Soares, H. (2016) TBBC in Encyclopedia of Signaling Molecules (Sangdun Choi, ed.) pp 1-8, Springer: New York. doi:10.1007/978-1-4614-6438-9_101508-1.
  • Marinho, H.S., Antunes F. (2015) Metabolism of superoxide radical and hydrogen peroxide in mitochondria in Mitochondria in Liver Disease (Derick Han and Neil Kaplowitz, ed.) Chapter 1, pp. 1- 28. Boca Raton: CRC Press.
  • Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006. ISI highly cited paper (Top 1% in Biology and Biochemistry)
  • Soares, H., Marinho H.S., Real, C., Antunes, F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr. 9, 371 doi: 10.1007/s12263-013-0371-5. Chosen as a key scientific article by Global Medical Discovery.
  • Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Role of hydrogen peroxide in NF-kB activation: from inducer to modulator. Antioxid. Redox Signal., 11, 2223-2243. [abstract][pdf]

Regulation of plasma membrane dynamics and lipid metabolism by hydrogen peroxide

 

  • Camelo, C., Vilas-Boas, F., Cepeda, A. P., Real, C., Barros-Martins, J., Pinto, F., Soares, H., Marinho, H.S., Cyrne, L. (2017) Opi1p translocation to the nucleus is regulated by hydrogen peroxide in Saccharomyces cerevisiae.  Yeast, 34, 383-395. doi:10.1002/yea.3240
  • Santos, F.C., Fernandes, A.S., Antunes, C.A.C., Moreira, F. P., Videira, A., Marinho, H.S., de Almeida, R.F.M. (2017) Reorganization of plasma membrane lipid domains during conidial germination. Biochim. Biophys. Acta - Molecular and Cell Biology of Lipids. 1862, 156-166. doi: 10.1016/j.bbalip.2016.10.011
  • Rodrigues, C., Mósca, A.F., Martins, A.P., Nobre, T., Prista, C., Antunes, F., Gasparovic, A.C., Soveral, G. (2016) Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress. International Journal of Molecular Science, 17, 2090. http://10.3390/ijms17122090
  • Marquês, J.T., Cordeiro, A.M., Viana A.S., Herrmann, A., Marinho, H.S., de Almeida, R.F. (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir, 31, 9410−9421 doi: 10.1021/acs.langmuir.5b02550
  • Marinho, H.S., Cyrne, L., Cadenas, E., Antunes, F. (2013) H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol. 526, 159-176. doi:10.1016/B978-0-12-405883-5.00010-7.
  • Marinho, H.S., Cyrne, L., Cadenas E., Antunes, F. (2013) The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol. 527, 3-19. doi:10.1016/B978-0-12-405882-8.00001-5.
  • Pedroso, N., Gomes-Alves, P., Marinho, H.S., Brito, V.B., Boada, C., Antunes, F., Herrero, E., Penque, D., Cyrne, L. (2012) The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Free Radical Res. 46, 1267-1279. doi:10.3109/10715762.2012.704997
  • Bastos, A.E.P., Marinho, H.S., Cordeiro, A.M., Soure, A.M., de Almeida, R.F.M. (2012) Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. Chem. Phys.  Lipids. 165, 577-588. doi:10.1016/j.chemphyslip.2012.06.002
  • Matias, A., Marinho, H.S., Cyrne, L., Herrero, E., Antunes, F. (2011) Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 515, 107-111, doi:10.1016/j.abb.2011.08.009.[abstract][pdf].
  • Aresta-Branco, F., Cordeiro, A.M., Marinho, H.S., Cyrne, L., Antunes, F., de Almeida, R.F.M. (2011) Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered, ergosterol-free, sphingolipid-enriched lipid rafts. J. Biol. Chem.,286, 5043-5054, doi:10.1074/jbc.M110.154435.[abstract][pdf].
  • Pedroso, N., Matias, A.C., Cyrne, L., Antunes, F., Borges, C., Malhó, R., de Almeida, R.F.M., Herrero, E. & Marinho, H.S. (2009) Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. Free Radic. Biol. Med. 46, 289-298.[abstract][pdf]
  • Folmer, V., Pedroso, N., Matias, A.C., Lopes, S.C.D.N., Antunes, F., Cyrne, L. & Marinho, H.S. (2008) H2O2 induces rapid biophysical and permeability changes in the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta - Biomembranes 1778, 1141-1147.[abstract][pdf]
  • Matias, A.C., Pedroso, N., Teodoro, N., Marinho, H.S., Antunes, F., Nogueira, J.M., Herrero, E., & Cyrne, L. (2007) Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. Free Radic. Biol. Med., 43, 1458-65.[abstract][pdf]
  • Sousa-Lopes, A., Antunes, F., Cyrne, L., Marinho, H.S. (2004) Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress. FEBS Lett. 578, 152-156. [abstract] [pdf]
  • Branco, M.R., Marinho, H.S., Cyrne, L., Antunes, F. (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem., 279, 6501-6506 [abstract] [pdf]

Redox regulation of gene expression and enzymes

 

  • Vilas-Boas, F., Bagulho, A., Jerónimo, A., Tenente, R., Real, C. Data on intracellular localization of RPSA upon alteration of its redox state. (2016) Data in Brief, 6, 311-315.
  • Vilas-Boas, F., Bagulho, A, Tenente, R, Teixeira, V.H., Martins, G., da Costa, G., Jerónimo, A., Cordeiro, C., Machuqueiro, M., Real, C. (2016) Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA. Free Radic. Biol. Med. 90:145-57. doi: j.freeradbiomed.2015.11.019.
  • Bagulho, A., Vilas-Boas, F., Pena, A., Peneda, C., Santos, F.C., Jerónimo, A., de Almeida, R.F.M.,  Real, C., (2015) The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells. Redox Biol., 6, 454–460. doi:10.1016/j.redox.2015.09.006
  • Marquês, J.T., Cordeiro, A.M., Viana A.S., Herrmann, A., Marinho, H.S., de Almeida, R.F. (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir, 31, 9410−9421. doi: 10.1021/acs.langmuir.5b02550
  • Marinho H.S., Real, C., Cyrne, L., Soares, H., Antunes, F. (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol. 2, 535-562. doi: 10.1016/j.redox.2014.02.006. ISI highly cited paper (Top 1% in Biology and Biochemistry)
  • Brito, P.M., Antunes, F. (2014) Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins. Front. Chem., 2014, 2:82. doi: 10.3389/fchem.2014.00082
  • Gomes, A.Q., Nolasco, S., Soares, H. (2013) Non-Coding RNAs: Multi-Tasking Molecules in the Cell. Int. J. Mol. Sci. 14,16010-39. doi: 10.3390/ijms140816010.
  • Oliveira-Marques, V., Silva, T., Cunha, F., Covas, G., Marinho, H.S., Antunes, F., Cyrne, L. (2013) A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-α. Redox Biol., 1, 347–352.doi:10.1016/j.redox.2013.05.004.
  • Cyrne, L., Oliveira-Marques, V., Marinho, H.S., Antunes, F. (2013) H2O2 in the induction of NF-κB-dependent selective gene expression. Methods Enzymol. 528, 173-188. doi:10.1016/B978-0-12-405881-1.00010-0.
  • Covas, G., Marinho, H.S., Cyrne, L., Antunes, F. (2013) Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation. Methods Enzymol. 528, 157-171. doi:10.1016/B978-0-12-405881-1.00009-4.
  • Rodrigues, J.R., Ferrer,R. Gamboa, N., Antunes, F. (2013) Potential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR) J. Enzyme Inhib. Med. Chem. 28: 1300-1306. DOI:10.3109/14756366.2012
  • Rodrigues,J.R., Charris, J., Camacho,J., Barazarte,A., Gamboa,N., Antunes, F. (2012) Cytotoxic effects of N´-formyl-2-(5-nitrothiophen-2-yl)benzothiazole-6-carbohydrazide in human breast tumor cells by induction of oxidative stress. Anticancer Research, 32, 2721-2726.
  • Matias, A., Marinho, H.S., Cyrne, L., Herrero, E., Antunes, F. (2011) Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 515, 107-111, doi:10.1016/j.abb.2011.08.009.[abstract][pdf].
  • Cyrne, L., Antunes, F., Sousa-Lopes, A., Diaz-Bérrio, J., Marinho, H.S. (2010) Glyceraldehyde-3-phosphate dehydrogenase is largely unresponsive to low regulatory levels of hydrogen peroxide in Saccharomyces cerevisiae. BMC Biochemistry, 11, 49.[abstract][pdf]
  • Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Role of hydrogen peroxide in NF-kB activation: from inducer to modulator. Antioxid. Redox Signal., 11, 2223-2243. [abstract][pdf]
  • Oliveira-Marques, V., Marinho, H.S., Cyrne, L. & Antunes, F. (2009) Modulation of NF-kB-dependent gene expression by H2O2: a major role for a simple chemical process in a complex biological response. Antioxid. Redox Signal., 11, 2043-2053.[abstract][pdf]
  • Oliveira-Marques, V., Cyrne, L., Marinho, H.S., Antunes, F. (2007) A quantitative study of NF-kB activation by H2O2: relevance in inflammation and synergy with TNF-alfa. J. Immunol. 178, 3893-3902. [abstract][pdf]
  • Cyrne, L., Martins, L., Fernandes, L., Marinho, H.S. (2003) Regulation of antioxidant enzymes gene expression in the yeast Saccharomyces cerevisiae during stationary phase. Free Radic. Biol. Med., 34, 385-393. [abstract][pdf]

Regulation of cytoskeleton and centrosome dynamics and cell polarity

 

  • Soares, H., Marinho H.S., Real, C., Antunes, F. (2014) Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr. 9, 371 doi: 10.1007/s12263-013-0371-5. Chosen as a key scientific article by Global Medical Discovery.
  • Cardoso, R., Nolasco, S., Gonçalves, J., Cortes, H.C., Leitão, A., Soares, H.  (2014)  Besnoitia besnoiti and Toxoplasma gondii: two apicomplexan strategies to manipulate the host cell centrosome and Golgi apparatus  Parasitology  3, 1-19. DOI: 10.1017/S0031182014000493.
  • Carranza, G., Castaño, R., Fanarraga, M.L., Villegas, J.C., Gonçalves, J., Soares, H., Avila, J., Marenchino, M., Campos-Olivas, R., Montoya, G., Zabala, J.C. (2013) Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics. Cell Mol Life Sci., 70, 357-371. DOI: 10.1007/s00018-012-1114-2 [pdf]
  • Nolasco S, Bellido J, Gonçalves J, Tavares A., Zabala, J.C., Soares, H. (2012) The Expression of Tubulin Cofactor A (TBCA) Is Regulated by a Noncoding Antisense Tbca RNA during Testis Maturation. PLoS One 7(8):e42536.[pdf]
  • Tavares, A., Gonçalves, J., Florindo, C. Tavares,A.A., Soares, H. (2012) Mob1: defining cell polarity for proper cell division. J. Cell Sci., 125, 516-527. doi: 10.1242/jcs.096610. Chosen as key scientific article by Global Medical Discovery.
  • Gonçalves, J., Nolasco, S., Nascimento, R., Lopez Fanarraga, M., Zabala, J.C., Soares, H.(2010) TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. EMBO Rep., 11, 194-200. [abstract][pdf]
  • Gonçalves, J., Tavares, A., Carvalhal, S.,Soares, H. (2010) Revisiting the tubulin folding pathway: new roles in centrosomes and cilia. Biomol. Concepts 1, 423â??434. [abstract][pdf]

Regulation of tissue response

 

  • C. Real, L. Remédio, F. Caiado, C. Igreja, C. Borges, A. Trindade, P. Pinto-do-Ó, H. Yagita, A. Duarte, S. Dias (2011) Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. PLoS One. 6:e18323. doi:10.1371/journal.pone.0018323
  • Real, C; Caiado, F; Dias, S. (2008) Endothelial progenitors in vascular repair and angiogenesis: how many are needed and what to do? Cardiovasc Hematol Disord Drug Targets, 8 ,185-93 [abstract][pdf]

Other relevant experimental papers

 

  • Marcelino, P., Marinho, H.S., Campos, M.C., Neves, A.R., Real, C., Fontes, F.S., Carvalho, A., Feio, G., Martins, M.B.F., Corvo, M.L. (2017) Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy. European J. Pharmacol. Sci. 109, 464-471.doi:10.1016/j.ejps.2017.09.008.
  • Pinto, R.V., Antunes, F., Pires,J., Graça, V., Brandão, P., Pinto, M.L. (2017) Vitamin B3 metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide. Acta biomaterialia 51, 66-74.
  • Guerreiro, P.S., Estácio, S.G., Antunes, F., Fernandes, A.S., Pinheiro, P.F., Costa, J.G., Castro, M., Miranda, J.P., Guedes, R.C., Oliveira, N.G. (2016) Structure-based virtual screening: towards the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chemical Biology & Drug Design, 88, 915–925.
  • Bento, R.N., Rendas, M.A., Semedo, V.A.R., Bernardes, C.E.S., Santos, M.S.C.S., Diogo, H.P., . Antunes, F., Minas da Piedade, M.E. (2016) The standard molar enthalpy of the base catalysed hydrolysis of methyl paraben revisited. Journal of Chemical Thermodynamics, 103, 176-180. doi: 10.1016/j.jct.2016.07.042
  • Fernandes, AC; Pinto, ML; Antunes, F; Pires, J (2016) Synthetic cobalt clays for the storage and slow release of therapeutic nitric oxide. RSC Advance, 6, 41195-41203. doi: 10.1039/C6RA05794B
  • Pinto, ML; Fernandes, AC; Antunes, F; Pires, J; Rocha J. (2016) Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues. Microporous and Mesoporous Materials, 229, 83-89. doi: doi:10.1016/j.micromeso.2016.04.021.
  • Cardoso R, Soares H, Hemphill A, Leitão A. (2016) Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology. 4:1-14. doi:10.1017/S0031182016000524
  • Fernandes, A.C., Pinto, M.L., Antunes, F., Pires, J. (2015) l-Histidine-based organoclays for the storage and release of therapeutic nitric oxide. Journal of Materials Chemistry B, 3, 3556-3563. DOI: 10.1039/C4TB01913J
  • Corvo, M.L., Marinho, H.S., Marcelino, P. Lopes, R., Vale, C.A., Marques, C., Martins L.C.D., Laverman, P., Storm, G., Martins, M.B.F. (2015) Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm. Res.32 :91-102. doi: 10.1007/s11095-014-1447-7.
  • Martins, M.B.F., Corvo, M.L., Marcelino, P., Marinho, H.S., Feio, G., Carvalho, A. (2014) New long circulating magnetoliposomes as contrast agents for detection of ischemia-reperfusion injuries by MRI.  Nanomed.-Nanotechnol. Biol. Med.10, 207-214. doi:10.1016/j.nano.2013.06.008.
  • da Silva, J.P., Antunes, F., Pinto, M.L., Fernandes, A. (2013) Clay based materials for storage and therapeutic release of nitric oxide. J. Mater. Chem. B., 1, 3287-3294.DOI: 10.1039/C3TB20535E
  • Antunes, F., Marinho, H.S., Barreto, M.C., Pavão, M.L. & Pinto, R.E. (2003) Diagnosis of enzyme inhibition based on the degree of inhibition. Biochim. Biophys. Acta, 1624, 11-20. [Abstract]

Mathematical modelling

 

  • Benfeitas, R., Selvaggio, G., Antunes, F., Coelho, P.M.B.M., Salvador, A. (2014) Hydrogen peroxide metabolism and sensing in human erythrocytes: a validated kinetic model and reappraisal of the role of peroxiredoxin II, Free Radic. Biol. Med. 74, 35-49. doi. 10.1016/j.freeradbiomed.2014.06.007.
  • M. Baptista, F.; Antunes, A. Silveira (2011) Diagnosis and optimization of the composting process in full-scale mechanical-biological treatment plants. Waste Management & Research29, 565-573. doi: 10.1177/0734242X10388061
  • Baptista, M; Antunes, F; Goncalves, MS; et al. (2010) Composting kinetics in full-scale mechanical-biological treatment plants. Waste Management, 30, 1908-1921.
  • Antunes F., Boveris, A., Cadenas. E. (2007) On the biologic role of the reaction of NO with oxidized cytochrome c oxidase. Antioxid. Redox Signal., 9,1569-79.[abstract]
  • Alves, R., Antunes, F., Salvador, A. (2006) Tools for kinetic modeling of biochemical networks. Nat. Biotechnol., 24, 667-762. [abstract]
  • Antunes F., Boveris, A., Cadenas. E. (2004) On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc. Natl. Acad. Sci. USA, 101,16774-16779. [abstract][pdf]